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DPM-1001 (oral or intraperitoneal administration
Chemical Name: 7-[(4-ethylpiperazin-1-yl)[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol
PS1145 is injected intracerebroventricular (icv) as a pretreatment to block hypothalamic inflammation induced by IL-4 in adult male Wistar rats consuming a high-fat diet (HFD) over an 11-day period
7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery
MJ33 (lithium salt) glanin DPM-1001 (oral or intraperitoneal administrationMJ33 is an inhibitor of the acidic, calcium independent (ai)PLA2 activity of Prdx6. Peroxiredoxin 6 (Prdx6), a bifunctional enzyme, has both non selenium glutathione peroxidase and phospholipase A2 (PLA2) activities. The PLA2 activity of Prdx6 is calcium independent, functions optimally in acidic conditions, and facilitates the intracellular processing of surfactant lipids, such as dipalmitoylphosphatidylcholine. In vitro: MJ33 was found to be